Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | diethyl 1H-pyrazole-3,5-dicarboxylate | HCID 142184 | — |
| 반응물 | 3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole | HCID 11150146 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester | HCID 60207951 | — |
반응 단계
To a solution of 1 g 1H-Pyrazole-3,5-dicarboxylic acid diethyl ester in 20 ml of DMF and 188 mg of sodium hydride (60% in mineral oil) were added at RT. After stirring for 20 min at room temperature 1.32 g of 3-bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole were added. The reaction was stirred at room temperature for 3 h. Then 100 ml water were added and the precipitating product was collected by filtration. Yield: 1.7 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429581B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-ac6f8b5ce4bf4aab908a7d48d79f7d5c |
| 출처 메모 | uspto-grants-2008_09 |