Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Ethyl 4-(furan-2-yl)-2,4-dioxobutanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Diethyl Oxalate | HCID 7268 | — |
| 반응물 | 2-Acetylfuran | HCID 14505 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl 4-(furan-2-yl)-2,4-dioxobutanoate | HCID 3006753 | — |
반응 단계
To a solution of 16 g oxalic acid diethyl ester in 350 ml THF, 10.1 g KOt-Bu were added at 0° C. Then 10 g 1-furan-2-yl-ethanone in 50 ml THF were added dropwise. After 1 h the reaction mixture was diluted with 300 ml ethyl acetate and 200 mnl water. This solution was acidified with diluted hydrochloric acid to pH 5. The organic layer was separated, washed with 150 ml water, dried over MgSO4, filtered and concentrated under reduced pressure to yield a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429581B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-4c8badb3b96b4d3aa4e6dc9d0f230fe0 |
| 출처 메모 | uspto-grants-2008_09 |