Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiophosgene → 3-Isothiocyanato-4-methoxypyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiophosgene | HCID 10040 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 3-Amino-4-methoxypyridine | HCID 5200343 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 3-Isothiocyanato-4-methoxypyridine | HCID 86665395 | — |
반응 단계
To a stirred mixture of 3-amino-4-methoxypyridine (2.01 g, 16.2 mmol) and NaHCO3 (4.08 g, 48.6 mmol) in CHCl3 and water (1:1, 50 mL) at 4° C. was added thiophosgene (1.5 mL, 19.6 mmol) dropwise. After completion of the addition, the ice bath was removed. The mixture was stirred for 4 hours, the organic layer was separated, and the aqueous layer was extracted with CH2Cl2. The combined organic phases were washed with water, dried over Na2SO4, filtered, and concentrated to give the title compound as brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08883473B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-db54b7916c324950a910de618568492c |
| 출처 메모 | uspto-grants-2014_11 |