Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-(2-Methoxybenzamido)thiophene-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 반응물 | 2-Methoxybenzoyl chloride | HCID 88969 | — |
| 반응물 | 3-Aminothiophene-2-carboxamide | HCID 518993 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(2-Methoxybenzamido)thiophene-2-carboxamide | HCID 59026641 | 80.4% |
반응 단계
A solution of 3-aminothiophene-2-carboxamide (0.90 g, 6.3 mmol), Et3N (0.97 mL, 7.0 mmol), and dimethylaminopyridine (0.15 g, 1.3 mmol) in CH2Cl2 (21 mL) was cooled in an ice bath, and 2-methoxybenzoyl chloride (1.1 g, 6.3 mmol) was added dropwise. The reaction was stirred for 1 h, and water (20 mL) was added. The solids were filtered, washed with water, and dried under vacuum to give 3-(2-methoxybenzamido)thiophene-2-carboxamide (1.4 g, 79% yield). LC/MS: m/z 277.3 (M+H)+ at 2.61 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08883781B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-e9da4b511b4b40488b3e67b40963f8f7 |
| 출처 메모 | uspto-grants-2014_11 |