Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Benzenamine, 5-methoxy-N-methyl-2-nitro-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Fluoro-4-nitroanisole | HCID 565654 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Benzenamine, 5-methoxy-N-methyl-2-nitro- | HCID 153056 | — |
반응 단계
83.5 mL (167.0 mmol) of a 2 molar solution of methylamine in THF are added dropwise to 14.3 g (83.56 mmol) 3-fluoro-4-nitro-anisol and 12.71 g (92.02 mmol) potassium carbonate in 200 mL dichloromethane. The mixture is stirred overnight and then combined with water. The organic phase is washed successively with water and ammonium chloride solution, dried and evaporated down. The yellow solid remaining is stirred with hexane. Yield: 12.7 g (84%); mass spectroscopy: [M+H]+=183.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429583B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-bc918e6a5f98444a864a487a48b4fb21 |
| 출처 메모 | uspto-grants-2008_09 |