Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-Methoxyphenyl)piperazine → 1-(2'-Chlorobiphenyl-2-ylmethyl)-4-(2-methoxyphenyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-Methoxyphenyl)piperazine | HCID 1346 | — |
| 반응물 | 2'-Chloro-[1,1'-biphenyl]-2-carbaldehyde | HCID 1392375 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 1-(Biphenyl-2-ylmethyl)-4-phenylpiperazine | HCID 71602523 | — |
| 생성물 | 1-(2'-Chlorobiphenyl-2-ylmethyl)-4-(2-methoxyphenyl)piperazine | HCID 71602688 | — |
반응 단계
69 mg of the target compound (0.18 mmol, 21.7%) was obtained using 1-(2-methoxyphenyl)piperazine (311 mg, 1.62 mmol), 2′-chlorobiphenyl-2-carbaldehyde (175 mg, 0.81 mmol) and NaBH(OAc)3 (523 mg, 2.43 mmol) according to the synthesis method of Compound 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08883796B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-413b741224ef49df82953419bac9267d |
| 출처 메모 | uspto-grants-2014_11 |