참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 4-Methoxybenzylamine | HCID 75452 | — |
| 반응물 | 3-Hydroxyphthalic anhydride | HCID 96580 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Hydroxy-2-(4-methoxy-benzyl)-isoindole-1,3-dione | HCID 59263145 | 81.1% |
반응 단계
A mixture of 3-hydroxyphthalic anhydride (543 mg, 3.31 mmol), 4-methoxybenzylamine (0.43 mL, 3.31 mmol) and acetic acid (3 mL) was heated at 100° C. for 4 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (760 mg, 81%). 1H NMR (DMSO-d6) 11.03 (1H, s), 7.61 (1H, dd), 7.28 (1H, d), 7.23-7.19 (3H, m), 6.89-6.86 (2H, m), 4.63 (2H, s), 3.71 (3H, s). MS: [M−H+] 282.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08883790B2 |
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| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-5953d9bd1da144b69a53be63945639e8 |
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| 출처 메모 | uspto-grants-2014_11 |
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