Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 5-(Benzyloxy)-2-chloropyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Chloro-5-hydroxypyridine | HCID 819821 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-(Benzyloxy)-2-chloropyridine | HCID 10013717 | 99.9% |
반응 단계
6-Chloropyridin-3-ol (30.00 g, 231.6 mmol), 1-(bromomethyl)benzene (43.57 g, 254.7 mmol), and potassium carbonate (80.01 g, 579.0 mmol) were added to DMF (500 mL) and stirred at ambient temperature overnight. Water was added and extracted with ether. The organic phase was washed with 1M NaOH, dried, filtered, and concentrated to provide the title compound (50.8 g, 99.86% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08883828B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-cf8d630a2c4040d8bce771347a161879 |
| 출처 메모 | uspto-grants-2014_11 |