Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 5-Bromo-3-(3-methoxyphenylthio)picolinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-Methoxybenzenethiol | HCID 84989 | — |
| 반응물 | 5-Bromo-3-nitropyridine-2-carbonitrile | HCID 2769698 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Bromo-3-(3-methoxyphenylthio)picolinonitrile | HCID 66994755 | 82% |
반응 단계
A 10 mL round-bottomed flask was charged with 5-bromo-3-nitropicolinonitrile (300 mg, 1.31 mmol), 3-methoxybenzenethiol (0.150 mL, 1.31 mmol), and DMF (12 mL). NaH (37.8 mg, 1.58 mmol) was added and reaction stirred at room temperature for 10 minutes. The reaction was poured into water and extracted with EtOAc. The organic layer was dried over sodium sulfate, filtered and concentrated. The resulting residue was purified on silica gel (10% EtOAc in Hexanes) to afford the title compound (345 mg, 81%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08883828B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-42fbcbf997444d6dadb900bddb096fd9 |
| 출처 메모 | uspto-grants-2014_11 |