참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl 3-amino-4-methylthiophene-2-carboxylate | HCID 123584 | — |
| 생성물 | 3-Amino-4-methylthiophene-2-carboxylic acid | HCID 14989678 | 65.2% |
반응 단계
Methyl 3-amino-4-methylthiophene-2-carboxylate (4.67 g, 27.3 mmol) and NaOH (2N in H2O, 68 mL, 136 mmol) were stirred at 100° C. for 1 hour. The solution was cooled to 0° C. and acidified to pH=5 with addition of concentrated HCl solution to form a precipitant. The solution was filtered and the solid was dried under vacuum to give the title compound (2.8 g, 65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08883828B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-cba1f244031f4341b4a05dc9c3581253 |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
