Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 335305생성일: 2026년 10월 24일
Dichloromethane → N-(5-(3,4-Difluorobenzylcarbamoyl)-2-fluorophenyl)-7-(6-formylpyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide
https://huagongshe.com/ko/reaction/335305
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbaldehyde | HCID 44754839 | — |
| 반응물 | 7-bromo-N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 71283181 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | N-(5-(3,4-Difluorobenzylcarbamoyl)-2-fluorophenyl)-7-(6-formylpyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 86695680 | — |
반응 단계
A mixture comprising 7-bromo-N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide (Intermediate 3A) (2.7 g, 5.36 mmol), 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde (1.375 g, 5.90 mmol) and cesium carbonate (6.99 g, 21.46 mmol) in DME (30 ml) and water (3 ml) was treated with PdCl2(dppf).CH2Cl2 adduct (0.219 g, 0.268 mmol). The mixture was placed under nitrogen and heated at 100° C. for 1 hr. The resulting mixture was concentrated in vacuo and the residue was dissolved in 10% trifluoroethanol/CHCl3. The organics were washed with water and NaHCO3 and concentrated in vacuo. Purification by chromatography on silica eluting with 0-30% 2M NH3 in MeOH/DCM afforded the title product;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08883819B2 |
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| 출처 데이터셋 | uspto-grants-2014_11 |
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| ORD ID | ord-3b77c0cc052b48ac95722199e5750bae |
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| 출처 메모 | uspto-grants-2014_11 |
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