Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluoropyridine-3-boronic acid → (S)-3-(3,3-difluoropyrrolidin-1-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)-5'-H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluoropyridine-3-boronic acid | HCID 2783270 | — |
| 반응물 | 3,3-Difluoropyrrolidine hydrochloride | HCID 24903482 | — |
| 반응물 | (S)-7-bromo-3-chloro-1-fluoro-5'H-spiro[chromeno[2,3-c]pyridine-5,4' oxazol]-2'-amine | HCID 58466258 | — |
| 생성물 | (S)-3-(3,3-difluoropyrrolidin-1-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)-5'-H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine | HCID 53464257 | — |
반응 단계
The title compound was synthesized by steps analogous to those described in method CC4 above, but using (S)-7-bromo-3-chloro-1-fluoro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (prepared by steps analogous to those described in Method BB33), 2-fluoropyridin-3-ylboronic acid and 3,3-difluoropyrrolidine hydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08883782B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-a9c6761ed3ed4a7eb56210b7c0ea2fd6 |
| 출처 메모 | uspto-grants-2014_11 |