1-Butanol, 4-methoxy- → 2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl]-1-(4-(6-(4-methoxy-butoxy)-pyrimidin-4-yl)-piperazin-1-yl)-ethanone

https://huagongshe.com/ko/reaction/336387

참여 물질

역할	이름	HCID	투입량
반응물	1-Butanol, 4-methoxy-	HCID 8107	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-chloro-pyrimidin-4-yl)-piperazin-1-yl)-ethanone	HCID 86690173	—
용매	N-methyl-2-pyrrolidone	HCID 13387	—
생성물	2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl]-1-(4-(6-(4-methoxy-butoxy)-pyrimidin-4-yl)-piperazin-1-yl)-ethanone	HCID 86690176	51%

반응 조건

온도	200 °C

반응 단계

50 mg 2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-chloro-pyrimidin-4-yl)-piperazin-1-yl)-ethanone and 53 mg 4-methoxy-1-butanol were added to 14 mg potassiumcarbonate in 2 mL n-methyl-2-pyrrolidinone. The reaction was sonicated for a few minutes and stirred 30 min at 200° C. The reaction was purified by HPLC to give 29 mg desired product. Rt: 1.82 min (method N), (M+H)+: 564

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08889677B2
출처 데이터셋	uspto-grants-2014_11
ORD ID	ord-402a91ef6b1045cebc0f7d5f64359313
출처 메모	uspto-grants-2014_11