참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 2(3H)-Benzofuranone, 3,3-dimethyl- | HCID 595620 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Hydroxy-alpha,alpha-dimethyl-benzeneacetamide | HCID 86663248 | — |
반응 단계
3,3-Dimethylbenzofuran-2(3H)-one (Example 198a, 19.7 g) was dissolved in 7N ammonia in methanol (50 mL) under nitrogen. The resulting solution was stirred at 25° C. for 16 h. The reaction mixture was evaporated to afford crude product. The solid was triturated with diethyl ether and filtered to give the subtitle compound (15.34 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08889692B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-8158e9f3f7074379993b11da7f2de2d8 |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
