Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → (S)-1-(3-bromo-2-methyloxyphenyl)heptane-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Borane;tetrahydrofuran | HCID 2723981 | — |
| 반응물 | 1-(3-Bromo-2-methyloxyphenyl)heptane-1-one | HCID 59544892 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (S)-1-(3-bromo-2-methyloxyphenyl)heptane-1-ol | HCID 59544894 | 98.3% |
반응 단계
Under room temperature, a 1M borane THF solution (48 mL) was added to an R-CBS 1M toluene solution (1.20 mL). 1-(3-Bromo-2-methyloxyphenyl)heptane-1-one (7, 13 g) was added, and the mixture was stirred for 1 hour. Methanol was added, a solvent was distilled off, and the residue was purified, by chromatography to obtain (S)-1-(3-bromo-2-methyloxyphenyl)heptane-1-ol (8, 12.86 g, yield 75%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08889722B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-f970433cb798446ca67ec67d8996e9c2 |
| 출처 메모 | uspto-grants-2014_11 |