Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dabco → 5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-4-yl)benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dabco | HCID 9237 | — |
| 반응물 | 5-Chloro-2,4-difluorobenzenesulphonyl chloride | HCID 2773527 | — |
| 반응물 | N-(2,4-Dimethoxybenzyl)pyrimidin-4-amine | HCID 63362995 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-4-yl)benzenesulfonamide | HCID 58042251 | 26% |
반응 단계
The reaction and aftertreatment were conducted in the same manner as in Example 14b by using the N-(2,4-dimethoxybenzyl)pyrimidine-4-amine (150 mg, 0.611 mmol) prepared in Example 14, 5-chloro-2,4-difluorobenzenesulfonyl chloride (302 mg, 1.22 mmol), 1,4-diazabicyclo[2.2.2]octane (137 mg, 1.22 mmol) and acetonitrile (5.0 mL), to yield the title compound (71.7 mg, 26%) as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08889741B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-778e7e044f18469199a3f044c4b1a920 |
| 출처 메모 | uspto-grants-2014_11 |