Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Difluoropyrimidine → N-(2,4-dimethoxybenzyl)-2-fluoropyrimidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Difluoropyrimidine | HCID 137716 | — |
| 반응물 | 2,4-Dimethoxybenzylamine | HCID 597250 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(2,4-dimethoxybenzyl)-2-fluoropyrimidin-4-amine | HCID 89963279 | 100% |
반응 단계
A solution of 2,4-difluoropyrimidine (1.00 g, 8.62 mmol) and 2,4-dimethoxybenzylamine (1.44 g, 8.62 mmol) in THF (28 mL) was stirred at room temperature for 1 hour. The reaction solution was vacuum concentrated, and the residue was purified with silica gel chromatography to yield the title compound (2.27 g, 62%) as a colorless amorphous solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08889741B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-8ef1271493224f55ad7ece80cb825aba |
| 출처 메모 | uspto-grants-2014_11 |