Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-(4-(4-(Benzyloxy)phenyl)oxazol-5-yl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Pyridinecarboxaldehyde | HCID 13389 | — |
| 반응물 | 1-((4-(Benzyloxy)phenyl)isocyanomethylsulfonyl)4-methylbenzene | HCID 86606417 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 4-(4-(4-(Benzyloxy)phenyl)oxazol-5-yl)pyridine | HCID 59797495 | 84% |
반응 단계
A mixture of 1-((4-(Benzyloxy)phenyl)isocyanomethylsulfonyl)4-methylbenzene (4.3 g, 11.4 mmol), isonicotinaldehyde (1.34 g, 12.5 mmol) and K2CO3 (3.15 g, 22.8 mmol) in methanol (96 mL ) and DME (30 mL) was heated at reflux for 5 h. After removal of solvent, the residue was purified by silica gel chromatography (2:1 hexane/EtOAc) to provide 2.29 g (84%) of a white solid. 1H NMR (400 MHz, CDCl3) δ: 5.12v (s, 2H), 7.03 (d, 2H), 7.46 (m, 6H), 7.56 (d, 2H), 7.61 (d, 2H), 8.02 (s, 1H), 8.58 (d, 2H). MS m/z: 329 [M+1]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429665B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-600b1aaedd034603afd57d4f4370a05a |
| 출처 메모 | uspto-grants-2008_09 |