Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triacetoxyperiodinane → (S)-tert-butyl 3-(benzyloxy)-1-oxopropan-2-ylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triacetoxyperiodinane | HCID 159087 | — |
| 반응물 | (R)-(+)-3-Benzyloxy-2-(Boc-amino)-1-propanol | HCID 11065873 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (S)-tert-butyl 3-(benzyloxy)-1-oxopropan-2-ylcarbamate | HCID 11196731 | 96% |
반응 단계
tert-Butyl N-[(1R)-2-(benzyloxy)-1-(hydroxymethyl)ethyl]carbamate (1.2 g, 4.3 mmole) was dissolved in CH2Cl2 (40 mL). Dess-Martin periodinane (2.4 g, 5.5 mmole) was added. The solution was stirred for 2 h at room temperature and then quenched with Na2S2O3 and saturated bicarbonate solution. After extracting with CH2Cl2, the organic layer was dried over MgSO4, filtered, and concentrated by rotary evaporation. Purification by chromatography (silica, 4/1: Hexane/EtOAc, Rf=0.4) afforded (S)-tert-butyl 1-(benzyloxy)-3-oxopropan-2-ylcarbamate as a white solid (1.1 g, 96%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08895497B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-1566ce787f12493aade5926d04773a8c |
| 출처 메모 | uspto-grants-2014_11 |