참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nitrogen | HCID 947 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2,8-Dibromoquinoline | HCID 45925951 | — |
| 반응물 | Vinylborate | HCID 86654342 | — |
| 촉매 | HCID 178418807 | HCID 178418807 | — |
| 용매 | Tetrahydrofuran 2-propanol | HCID 22597222 | — |
| 용매 | Water ethylacetate | HCID 22728543 | — |
| 생성물 | 8-Bromo-2-vinylquinoline | HCID 67234780 | — |
반응 단계
To 2,8-dibromoquinoline (1.836 g, 6.398 mmol) in THF/IPA (20 mL/10 mL) was added vinylborate (0.9428 g, 7.038 mmol) and triethylamine (0.7769 g, 7.678 mmol). The reaction mixture was purged with N2, and PdCl2(dppf) dichloromethane adduct (0.3685 g, 0.4479 mmol) was added. The reaction was stirred at 55° C. for 12 hours, then cooled to ambient temperature. The reaction mixture was diluted with EtOAc/H2O, and the organic layer was separated and concentrated to provide the crude product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08895550B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-038c80a14fc94d0f85367248780f1fd4 |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
