참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1,4-Dioxane-2,3-diol | HCID 96170 | — |
| 반응물 | 1-(4-Methoxyphenyl)ethanamine | HCID 238181 | — |
| 반응물 | 6-Chloro-2-methylpyrimidine-4,5-diamine | HCID 594145 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Ethyl acetate hexane | HCID 21226206 | — |
| 생성물 | [1-(4-Methoxyphenyl)ethyl]-2-methylpteridin-4-yl-amine | HCID 58174228 | 21.3% |
반응 단계
A mixture of 6-chloro-4,5-diamino-2-methylpyrimidine (317 mg, 2.0 mmol) and 1,4-dioxane-2,3-diol (240 mg, 2.0 mmol) in EtOH (15 mL) was stirred at 25° C. for 1 h. TLC analysis (1:1 hexane/EtOAc on SiO2) indicated complete consumption of starting material. 1-(4-Methoxyphenyl)-ethylamine (332 mg, 2.2 mmol) and triethylamine (Et3N, 0.3 mL, 2.2 mmol) were added, and the reaction was stirred overnight. The majority of solvent was removed in vacuo and the residue was partitioned between EtOAc and H2O. The organic layer was concentrated in vacuo to leave a brown residue that was purified by column chromatography over SiO2, eluting with 2:1 EtOAc/hexane, then 100% EtOAc to afford [1-(4-methoxyphenyl)ethyl]-2-methylpteridin-4-yl-amine (126 mg) as a brown oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08895568B2 |
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| 출처 데이터셋 | uspto-grants-2014_11 |
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| ORD ID | ord-f24ae463ec024ff493a47364f93602d2 |
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| 출처 메모 | uspto-grants-2014_11 |
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