Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → HCID 15342494, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| 반응물 | Thieno[2,3-b]pyridin-3-amine | HCID 289923 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 15342494 | HCID 15342494 | 85.5% |
반응 단계
1,3-Dicyclohexylcarbodiimide (11 g) was added with stirring to a solution of 3-aminothieno[2,3-b]pyridine (8 g) and N-(tert-butoxycarbonyl)glycine (10 g) in 200 mL of dichloromethane. After one hour the reaction mixture was filtered to remove the separated 1,3-dicyclohexylurea and evaporated to an oil. Crystallization from ethyl ether afforded 14 g of a solid, m.p. 190°-192° C. Recrystallization of 3 g from acetonitrile afforded 2.4 g of crystals, m.p. 192°-194° C. Final recrystallization from acetonitrile afforded 2.0 g of crystals, m.p. 194°-196° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05856335 |
| 출처 데이터셋 | uspto-grants-1999_01 |
| ORD ID | ord-091f20146d8944a185bba925e92f47fe |
| 출처 메모 | uspto-grants-1999_01 |