참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1-Iodopropane | HCID 33643 | — |
| 반응물 | 5-Nitrovanillin | HCID 81134 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-Methoxy-4-propoxy-5-nitrobenzaldehyde | HCID 12080646 | — |
반응 단계
A mixture of sodium hydride (6.09 g, 152.3 mmole) in 20 mL of dry dimethylformamide (DMF) was cooled to 0° C. and then 5-nitrovanillin (25 g, 126.8 mmole) in 41 mL of DMF was added dropwise. After 30 minutes, propyl iodide (25.87 g, 152.0 mmole) was added dropwise at 0° C. When the addition was completed, the reaction was maintained at room temperature for 2 hours and then stirred overnight at 70° C. Water was added, and-the solution extracted with ethyl ether, washed with 10% NaOH, dried over MgSO4, filtered and then evaporated in vacuo to an oil (19 g, 62.7%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05856323 |
|---|
| 출처 데이터셋 | uspto-grants-1999_01 |
|---|
| ORD ID | ord-8f49f7f7e9ae486e8407a7c3e007b6d7 |
|---|
| 출처 메모 | uspto-grants-1999_01 |
|---|
