참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 5-Nitrovanillin | HCID 81134 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3,4-Dimethoxy-5-nitrobenzaldehyde | HCID 10867565 | — |
반응 단계
A suspension of sodium hydride (4.87 g, 121.7 mmole) in 18 mL dry DMF was cooled to 0° C. and then 5-nitrovanillin (20 g, 101.4 mmole) in 30 mL of DMF was added dropwise. After 30 minutes, methyl iodide (43.18 g, 304.2 mmole) was added dropwise at 0° C. When the addition was completed, the mixture was warmed to room temperature and stirred overnight. Water was added and the solution extracted with ethyl ether, the organic layer was washed with 10% NaOH solution, dried over MgSO4, filtered and evaporated in vacuo to an oil (8.7 g, 40.7%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05856323 |
|---|
| 출처 데이터셋 | uspto-grants-1999_01 |
|---|
| ORD ID | ord-199b9efcfdb54d4e868c96008a8f708e |
|---|
| 출처 메모 | uspto-grants-1999_01 |
|---|
