Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalic Acid → 4-(2-Tetrahydropyran-2-yloxyethyl)phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalic Acid | HCID 971 | — |
| 반응물 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 반응물 | Tyrosol | HCID 10393 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Sodium Sulfate | HCID 24436 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(2-Tetrahydropyran-2-yloxyethyl)phenol | HCID 14208783 | — |
반응 단계
Oxalic acid (64 g, 0.5 mol), Na2SO4 (400 g) and distilled dihydropyran (600 mL) are added to a solution of 4-(2-hydroxyethyl)phenol (600 g, 4.3 mol) in acetone (3 l) and the mixture stirred for 3 hours. The resulting solution is added to water (4 l) containing 35% NaOH solution (500 mL), and washed with CH2Cl2 (2X). The mixture was stirred vigorously for one hour. The organic phase was washed with water (3×1 l) and evaporated to yield 4-(2-tetrahydropyran-2-yloxyethyl)phenol (9).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04761420 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-1d2b9189a80b40619fd519eb29ed46e4 |
| 출처 메모 | uspto-grants-1988_08 |