Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Methyl 3-amino-2-chloro-5-fluoro-4-methylbenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid | HCID 13657440 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Methyl 3-amino-2-chloro-5-fluoro-4-methylbenzoate | HCID 13657452 | — |
반응 단계
12 g of 3-amino-2-chloro-5-fluoro-4-methylbenzoic acid are initially introduced into 60 ml of MeOH. HCl gas is passed in for 20 minutes and is then boiled under reflux for 5 hours. Thereafter, the mixture is poured into water and rendered alkaline with sodium carbonate and the product is isolated. Yield: 8 g, melting point: 51°-52°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04762844 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-be8a1afed337406c888ecd39e8cf4276 |
| 출처 메모 | uspto-grants-1988_08 |