Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 5-t-Butyl-2-(4-ethynylphenyl)-1,3-oxathiane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | 4-Ethynylbenzaldehyde | HCID 2771645 | — |
| 반응물 | HCID 19990620 | HCID 19990620 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 5-t-Butyl-2-(4-ethynylphenyl)-1,3-oxathiane | HCID 19990626 | — |
반응 단계
A solution of 3,3-dimethyl-2-mercaptomethylbutan-1-ol (1.46 g), 4-ethynylbenzaldehyde (1.30 g) (W.B. Austin et al. J. Org. Chem., 1981, 46. 2280) and para-toluenesulphonic acid (10 mg) in benzene (50 ml) was heated to reflux overnight under Dean and Stark conditions. The resulting solution was evaporated under reduced pressure and the residue was purified on silica. Elution with 4:1 hexane: dichloromethane gave 5-t-butyl-2-(4-ethynylphenyl)-1,3-oxathiane as a mixture of isomers.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05061726 |
| 출처 데이터셋 | uspto-grants-1991_10 |
| ORD ID | ord-c9cf745b0adf40639ca7aee192e3a0dc |
| 출처 메모 | uspto-grants-1991_10 |