Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-acetyl-N-methoxybenzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Acetylbenzenesulfonyl chloride | HCID 266418 | — |
| 반응물 | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-acetyl-N-methoxybenzenesulfonamide | HCID 21082525 | 65.8% |
반응 단계
Ex-30A: To a solution of 4-acetylbenzenesulfonyl chloride (2.18 g, 10.0 mmol) in 100 ml of THF at 0° C., Et3N (2.5 g, 25 mmol) was added followed by O-methyl hydroxyamine hydrochloride (0.84 g, 10 mmol). The mixture was stirred for 1 hr at room temperature and then poured into water, and the precipitate was filtered and dried. Recrystallization from THF/hexanes gave 1.5 g (65.8%) of 4-acetyl-N-methoxybenzenesulfonamide as a white solid. 1H-NMR (300 MHz, CDCl3) δ 8.10 (d, J=8 Hz, 2H), 8.03 (d, J=8 Hz, 2H), 7.23 (brs, 1H), 3.82 (s, 3H), 2.66 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07173129B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-2bd081d3498142daa8aac276c99843da |
| 출처 메모 | uspto-grants-2007_02 |