Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1,1-Trifluoro-2-isothiocyanatoethane → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| 반응물 | 4-Amino-2-(4-phthalimidobutyl)pyrimidine | HCID 20450337 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine | HCID 54214531 | 69.8% |
반응 단계
A mixture of 4-amino-2-(4-phthalimidobutyl)pyrimidine (1 g.), 2,2,2-trifluoroethylisothiocyanate (1 g.) and acetonitrile was stirred at 70° for 18 hours. The mixture was diluted with acetonitrile (10 ml.), cooled in ice and then filtered to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine (1.03 g.), m.p. 204°-205°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04762932 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-ca82245d01c64c8aa746d59c200086f1 |
| 출처 메모 | uspto-grants-1988_08 |