Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 2-Methylene-3-quinuclidone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Methylene-3-quinuclidinone dihydrate hydrochloride | HCID 21954275 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Methylene-3-quinuclidone | HCID 322973 | 100% |
반응 단계
A mixture of 2-methylene-3-quinuclidinone dihydrate hydrochloride (27.2 g, 0.13 mol, 1 eq) and K2CO3 (86.0 g, 0.62 mol, 4.8 eq) is dissolved in 130 mL water and 250 mL CH2Cl2 and stirred vigorously. After 3 days, the layers are separated and the aqueous layer is extracted with CH2Cl2. The combined organic layers are dried (MgSO4), filtered and concentrated to give 17.8 g (100%) of 2-methylenequinuclidin3-one as a yellow oil. MS (ESI) for C8H11NO m/z 138.1 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07176198B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-97963cac6149420c81d4ebb0fdaae399 |
| 출처 메모 | uspto-grants-2007_02 |