참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Methanesulfonic Acid | HCID 6395 | — |
| 반응물 | 2-Amino-4,6-dimethyl pyrimidine | HCID 13021 | — |
| 반응물 | m-Toluenesulfonic acid | HCID 105362 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4,6-Dimethyl-2-(4-tolylsulfonylmethylamino)pyrimidine | HCID 23043221 | — |
반응 단계
12.7 g (0.1 mole) of 2-amino-4,6-dimethylpyrimidine are suspended in 200 ml of water and then 9.7 g (0.1 mole) of methanesulfonic acid are stirred in to form a solution. To the stirred solution are added, in succession, 18.22 g (0.1 mole) of toluene-3-sulfonic acid, sodium salt, and 9.4 g (0.11 mole) of aqueous 35% formaldehyde. The mixture is stirred for 2 hours at room temperature and for another 30 minutes at 90° C. The colourless precipitate is filtered with suction after cooling and dried. Melting point: 191°-194° C. Yield: 25 g (86% of theory).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04764203 |
|---|
| 출처 데이터셋 | uspto-grants-1988_08 |
|---|
| ORD ID | ord-7d967ee7c54f4a10ad23c52de03dd4d0 |
|---|
| 출처 메모 | uspto-grants-1988_08 |
|---|
