Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 4-Methoxy-6-methyl-2-(1,2,4-triazol-1-ylmethylamino)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | 1H-1,2,4-Triazole | HCID 9257 | — |
| 반응물 | 4-Methoxy-6-methylpyrimidin-2-amine | HCID 587236 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-Methoxy-6-methyl-2-(1,2,4-triazol-1-ylmethylamino)pyrimidine | HCID 23043232 | — |
반응 단계
With stirring, a mixture of 13.9 g (0.1 mole) of 2-amino-4-methoxy-6-methylpyrimidine, 7 g (0.1 mole) of 1,2,4-triazole, 9.4 g (0.11 mole) of aqueous 35% formaldehyde and 1 g of acetic acid in 100 ml of methanol is refluxed for 11/2 hours. First a clear solution forms, from which the reaction product precipitates in crystalline form after a time. After the reaction mixture has cooled, the crystalline title compound is filtered with suction and dried. Yield: 14 g. Melting point: 191°-193° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764203 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-3db3d2bd444c48ce94a338689e4a7c66 |
| 출처 메모 | uspto-grants-1988_08 |