참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl 1-butylindoline-6-carboxylate | HCID 21086137 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-Butylindoline-6-carboxylic acid | HCID 21085176 | 77.1% |
반응 단계
To a mixture of Methyl 1-butylindoline-6-carboxylate (1.6 g) in methanol (20 mL) was added 1N NaOH (5.0 mL). The mixture was heated at 60° C. for 2 h then cooled to room temperature, poured into 1N HCl and extracted into ethyl acetate. The ethyl acetate extract was dried over anhydrous magnesium sulfate and concentrated to give 1.16 g of the title compound: 1H NMR (CDCl3) δ 0.974, 1.43, 1.60, 3.01, 3.11, 3.42, 7.1, 7.43.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07176242B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_02 |
|---|
| ORD ID | ord-14412c7ca1144ab284fbc28f05b7c03a |
|---|
| 출처 메모 | uspto-grants-2007_02 |
|---|
