Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-(5,6,7,8-Tetrahydroquinol-8-yl)propylamino-3-nitro-5-(pyrid-3-ylmethyl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-(5,6,7,8-Tetrahydroquinol-8-yl)propylamine | HCID 19851779 | — |
| 반응물 | 2-Chloro-3-nitro-5-(pyrid-3-ylmethyl)pyridine hydrochloride | HCID 19851787 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(5,6,7,8-Tetrahydroquinol-8-yl)propylamino-3-nitro-5-(pyrid-3-ylmethyl)pyridine | HCID 19851797 | 86.5% |
반응 단계
A mixture of 3-(5,6,7,8-tetrahydroquinol-8-yl)propylamine (4.5 g), 2-chloro-3-nitro-5-(pyrid-3-ylmethyl)pyridine hydrochloride (5 g) and triethylamine (10 ml) was refluxed in ethanol (200 ml) for 7.5 hours. The solvent was removed in vacuo, the residue was dissolved in chloroform and chromatographed on silica in chloroform and later chloroform/methanol 4:1. The fractions containing the product were concentrated to give the title compound as an oil (6.1 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764519 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-4bfa4c33e2054304a26c369a1db80481 |
| 출처 메모 | uspto-grants-1988_08 |