Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 4-tert-Butoxycarbonyl-1-[(6-chloronaphthalen-2-yl)sulfonyl]-2-ethoxycarbonylpiperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 6-Chloronaphthalene-2-sulfonyl chloride | HCID 10635129 | — |
| 반응물 | 1-tert-Butyl 3-ethyl piperazine-1,3-dicarboxylate | HCID 11402671 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-tert-Butoxycarbonyl-1-[(6-chloronaphthalen-2-yl)sulfonyl]-2-ethoxycarbonylpiperazine | HCID 69700224 | — |
반응 단계
In dichloromethane (18 ml), 1-tert-butoxycarbonyl-3-ethoxycarbonylpiperazine (517 mg) and 6-chloro-2-naphthylsulfonyl chloride (588 mg) were dissolved under ice cooling. To the resulting solution, diisopropylethylamine (0.59 ml) was added, followed by stirring at room temperature for 63 hours. The residue obtained by distilling off the solvent under reduced pressure was purified by chromatography on a silica gel column (hexane:ethyl acetate=3:1), whereby the title compound (688 mg, 71%) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06747023B1 |
| 출처 데이터셋 | uspto-grants-2004_06 |
| ORD ID | ord-49e9655c06184cefb9e063ca7e5b7913 |
| 출처 메모 | uspto-grants-2004_06 |