Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetyl chloride → beta-(p-Chloroacetylaminobenzoyl)-propionic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | 4-(4-Aminophenyl)-4-oxobutanoic acid | HCID 243290 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | beta-(p-Chloroacetylaminobenzoyl)-propionic acid | HCID 20507196 | 90.4% |
반응 단계
20 g (103 millimoles) of β-(p-aminobenzoyl)-propionic acid and 12.9 g (114 millimoles) of chloroacetyl chloride, together with 200 ml of absolute toluene, are kept for 4 hours at 80° C. The product is filtered off at 10° C., washed with water and dried under reduced pressure at 50° C. 25.1 g (90% of theory) of β-(p-chloroacetylaminobenzoyl)-propionic acid are isolated as light brown crystals which, after recrystallization from acetone, melt at 184°-185° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04376771 |
| 출처 데이터셋 | uspto-grants-1983_03 |
| ORD ID | ord-da3c5c0beedc4de2ba281a95f4d9df2d |
| 출처 메모 | uspto-grants-1983_03 |