Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[6-bromo-5-(o-chlorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepin-7yl]-3-(2-hydroxyethyl)urea → 7-amino-6-bromo-5-(o-chlorophenyl)-1,3-dihydro-1,3,3-trimethyl-2H-1,4-benzodiazepin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[6-bromo-5-(o-chlorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepin-7yl]-3-(2-hydroxyethyl)urea | HCID 20506137 | — |
| 반응물 | [6-bromo-5-(o-chlorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepin-7-yl]isocyanate | HCID 20506177 | — |
| 용매 | Acetone diethylether | HCID 21584533 | — |
| 생성물 | 7-amino-6-bromo-5-(o-chlorophenyl)-1,3-dihydro-1,3,3-trimethyl-2H-1,4-benzodiazepin-2-one | HCID 20506136 | — |
반응 단계
From 4.5 g (0.011 mol) of 7-amino-6-bromo-5-(o-chlorophenyl)-1,3-dihydro-1,3,3-trimethyl-2H-1,4-benzodiazepin-2-one there is obtained, in analogy to the details in Example 4, via [6-bromo-5-(o-chlorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepin-7-yl]isocyanate, 1-[6-bromo-5-(o-chlorophenyl)-2,3-dihydro-1,3,3-trimethyl-2-oxo-1H-1,4-benzodiazepin-7yl]-3-(2-hydroxyethyl)urea of melting point 214°-218° (acetone/ether).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04377522 |
| 출처 데이터셋 | uspto-grants-1983_03 |
| ORD ID | ord-79364905c46f4d39a9391a8f70bc829a |
| 출처 메모 | uspto-grants-1983_03 |