참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Dimethyl methoxymethylenemalonate | HCID 90770 | — |
| 반응물 | 4-Amino-6-(2-ethylbutyramido)quinazoline | HCID 13060462 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate | HCID 13060503 | 56.1% |
반응 단계
A mixture of 4-amino-6-(2-ethylbutyramido)quinazoline (5.58 g), dimethyl methoxymethylenepropanedioate (5.62 g) and N,N-dimethylformamide (22 ml) was stirred at 100° C. for 1.5 hours. After cooling to ambient temperature, water (90 ml) was added to the reaction mixture. The resulting solid was separated by filtration, washed with water and dried to give dimethyl [[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate (4.85 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04377580 |
|---|
| 출처 데이터셋 | uspto-grants-1983_03 |
|---|
| ORD ID | ord-6ac3ed39b7914879bb8f583030772233 |
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| 출처 메모 | uspto-grants-1983_03 |
|---|
