Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hexahydro-1H-azepine-1-ethanol → 2-Homopiperidinylethyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hexahydro-1H-azepine-1-ethanol | HCID 88615 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | Methyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate | HCID 21294482 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Homopiperidinylethyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate | HCID 57191089 | 60% |
반응 단계
By treating 17.31 g of methyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate (II, R=CF3, R"=CH3), 10.5 g of 1-(2-hydroxyethyl)homopiperidine in 130 ml of toluene and in the presence of sodium as described in Example 1, 20.6 g of a crude material are isolated. The recrystallization in diisopropyl ether enables to isolate 13.7 g (yield: 60%) of a whitish solid with m.p. 72°-75° C. and elemental analysis C, H, N, F correct.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04767767 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-c3bbe4b8f5e24016b2ea00501c262a89 |
| 출처 메모 | uspto-grants-1988_08 |