Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Methylhydrazinecarbothioamide → N-Methyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Methylhydrazinecarbothioamide | HCID 2723853 | — |
| 반응물 | N-Methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide | HCID 15595702 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-Methyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]acetamide | HCID 15595689 | 30.9% |
반응 단계
A solution of 6.0 g N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide and 4.8 g 4-methylthiosemicarbazide in 200 ml ethanol was refluxed for 5 hours and treated in similar fashion in Example 67. Chromatography on silica gel with dichloromethane-methanol (96:4) and recrystalization from dichloromethane-hexane afforded 2.1 g yellow crystals, mp 213°-215° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04767765 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-068f8c38ae0d447b911a6b90870572bf |
| 출처 메모 | uspto-grants-1988_08 |