Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → HCID 178419015, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Triethylamine hydrobromide | HCID 12493 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 4-tert-Butylbenzonitrile | HCID 77883 | — |
| 반응물 | Lithium Chloride | HCID 433294 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178419015 | HCID 178419015 | 70.7% |
반응 단계
In a 250 ml round-bottomed flask fitted with reflux condenser, 4.9 g of p-t-butylbenzonitrile, 3.82 g of lithium chloride and 5.85 g of sodium azide and 8.2 g of triethylammonium bromide in 100 ml of DMF are heated at 120° C. for 8 hours. After cooling to room temperature, 100 ml of water are added and the mixture is admixed in an ice bath with dilute hydrochloric acid until no further solid precipitates. The precipitate is filtered off with suction, washed with water and dried. Recrystallization from ethanol/water gives 4.4 g of colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05840217 |
| 출처 데이터셋 | uspto-grants-1998_11 |
| ORD ID | ord-31833a1e0ad14612875a81cff3bd5702 |
| 출처 메모 | uspto-grants-1998_11 |