Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbon tetrabromide → tert-Butyl 2-(2,2-dibromoethenyl)pyrrolidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbon tetrabromide | HCID 11205 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate | HCID 2734674 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | tert-Butyl 2-(2,2-dibromoethenyl)pyrrolidine-1-carboxylate | HCID 14730280 | 47.9% |
반응 단계
Following the procedure of Example 3, 6.8 g of (S)-2-formyl-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester in 20 ml of methylene chloride is reacted with 40 g of triphenylphosphine, 26 g of carbon tetrabromide in 700 ml of methylene chloride to give 5.8 g of the desired product as a colorless solid, mp 58°-59° C., [α]D26° =+24°±1 (C=1.048%, methylene chloride).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05001142 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-b67f8ac7f60d4737b2e9d3e9ec551415 |
| 출처 메모 | uspto-grants-1991_03 |