Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfoxide → 2-(2-Hydroxyethylthio)naphthacene-5,12-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | 2-Mercaptoethanol | HCID 1567 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Fluorotetracene-5,12-dione | HCID 20089828 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-(2-Hydroxyethylthio)naphthacene-5,12-dione | HCID 20065414 | — |
반응 단계
1 g (3.62 mmol) of 2-fluoronaphthacene-5,12-dione (prepared according to U.S. Pat. No. 4,522,754), 0.31 g (3.98 mmol) of 2-mercaptoethanol, 1.50 g (10.86 mmol) of potassium carbonate and 10 ml of DMSO are stirred at 25° C. for 3 minutes. The mixture is poured into water. The crystals are filtered off and dissolved in tetrahydrofuran/toluene, the solution dried over sodium sulfate and evaporated. The residue is recrystallized from THF/toluene/pentane. Yield 1 g (83%); melting point 195°-196° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05001243 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-5a1d892617ac412782763614347f542f |
| 출처 메모 | uspto-grants-1991_03 |