Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nicotinic Acid → N-Nicotinoyltyrosine ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nicotinic Acid | HCID 938 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | Tyrosine ethyl ester hydrochloride | HCID 2724939 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | N-Nicotinoyltyrosine ethyl ester | HCID 53849020 | — |
반응 단계
Nicotinic acid (12.3 g, 0.1 mol) was dissolved in dry pyridine (300 mL). The solution was cooled and dicyclohexylcarbodiimide (20.6 g, 0.1 mol) was added. After dissolution, tyrosine ethyl ester hydrochloride (24.6 g, 0.1 mol) was added and the solution was stirred overnight. The precipitated dicyclohexylurea (DCU) was removed by filtration. Additional DCU was removed by triturating the oil with hot water. The product was purified with acetone. Calculated for C17H18N2O4 ·1/2H2O: C, 63.16; H, 5.88; N, 8.66. Found: C, 63.10; H, 5.96; N, 8.59. The product can also be named N-[1-ethoxycarbonyl-2-(4'-hydroxyphenyl)ethyl]nicotinamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05002935 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-901a1eca85a745b5876f3468b4901567 |
| 출처 메모 | uspto-grants-1991_03 |