Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluorobenzoyl chloride → 4''-[3-Butyl-5-oxo-1-(2-trifluoromethyl-phenyl)-1,5-dihydro-[1,2,4]triazol-4-ylmethyl]-biphenyl-2-sulfonic acid 4-fluoro-benzoylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| 반응물 | 5-n-Butyl-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one | HCID 10346902 | — |
| 생성물 | 4''-[3-Butyl-5-oxo-1-(2-trifluoromethyl-phenyl)-1,5-dihydro-[1,2,4]triazol-4-ylmethyl]-biphenyl-2-sulfonic acid 4-fluoro-benzoylamide | HCID 10009478 | 93% |
반응 단계
The title compound was prepared in 93% yield by reaction of 5-n-butyl-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Example 16, Step C) with 4-fluorobenzoyl chloride according to the procedure of Example 13, Step C. Column chromatography on silica gel (gradient elution with 0.5-5% MeOH in CH2Cl2) provided the material as cream-colored crystals, mp 120°-122° C.; satisfactory purity by TLC in 9:1 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 691 (M+K)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411980 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-74b4fa3d7f444162b4fb36ce2c42d983 |
| 출처 메모 | uspto-grants-1995_05 |