Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1'-Biphenyl, 4'-(bromomethyl)-2-nitro- → 5-n-Butyl-2,4-dihydro-4-[(2'-nitrobiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1'-Biphenyl, 4'-(bromomethyl)-2-nitro- | HCID 11779072 | — |
| 반응물 | 5-n-Butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one | HCID 135527027 | — |
| 생성물 | 5-n-Butyl-2,4-dihydro-4-[(2'-nitrobiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one | HCID 10480946 | 91% |
반응 단계
By the procedure of Example 13, Step A, 5-n-butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Example 16, Step A) was alkylated with (2'-nitrobiphenyl-4-yl)methyl bromide (from Step B). Flash chromatography of the crude product on silica gel (gradient elution with 0.5-5% MeOH in CH2Cl2) gave a 91% yield of the title compound as a sticky foam; satisfactory purity by TLC in 98:2 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 497 (M+1)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411980 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-f2f1662e807d4ece871809d2e3d42225 |
| 출처 메모 | uspto-grants-1995_05 |