5-n-Butyl-2-[alpha-(carbomethoxy)benzyl]-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one → HCID 178441940, 화합물

https://huagongshe.com/ko/reaction/36211

참여 물질

역할	이름	HCID	투입량
반응물	5-n-Butyl-2-[alpha-(carbomethoxy)benzyl]-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one	HCID 19939404	—
용매	Acetic Acid	HCID 176	—
생성물	HCID 178441940	HCID 178441940	96%

반응 조건

온도	65 °C

반응 단계

Deprotection of 5-n-butyl-2-[α-(carbomethoxy)benzyl]-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one in 67% aqueous acetic acid was accomplished by the procedure of Example 3, Step B, except the mixture was heated overnight at 65° C. After work-up, the residue was flash chromatographed over silica gel (30 mL for 0.14 mmole, elution with 4-10% MeOH/CH2Cl2) to give the title compound in 96% yield as an off-white foam, homogeneous by TLC in 9:1 CH2Cl2 /MeOH, mass spectrum (FAB) m/e 524 (M+1)+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05411980
출처 데이터셋	uspto-grants-1995_05
ORD ID	ord-2136635ee3b94f2d8c01ff81db6cf87b
출처 메모	uspto-grants-1995_05