Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Amino-3-hydroxypyridine → N,N-Diethyl-N'-(3-hydroxypyridin-4-yl)methanimidamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Amino-3-hydroxypyridine | HCID 2762419 | — |
| 반응물 | N-(Dimethoxymethyl)-N-ethylethanamine | HCID 12747026 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N,N-Diethyl-N'-(3-hydroxypyridin-4-yl)methanimidamide | HCID 15380930 | 61.5% |
반응 단계
A mixture of 4-amino-3-pyridinol (3.90 g), N,N-diethylformamide dimethyl acetal (11.68 g) and toluene (20 mL) was heated under nitrogen for 2 hours. The solution was concentrated under reduced pressure. The resulting liquid was filtered through silica gel with 10% ethanol in tetrahydrofuran to give a solid. Recrystallization of the purified product from ethyl acetate/hexanes afforded 4.21 g of crystalline solid, m.p. 104°-106° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05869480 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-dde421b6039e4c96ad8bffc105b8387a |
| 출처 메모 | uspto-grants-1999_02 |