Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Methylcyclohexylamine → 4-[[(N-cyclohexyl-N-methylamino)methylene]amino]-3-pyridinol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Methylcyclohexylamine | HCID 7514 | — |
| 반응물 | 4-[[(Dimethylamino)methylene]amino]-3-pyridinol | HCID 15380929 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-[[(N-cyclohexyl-N-methylamino)methylene]amino]-3-pyridinol | HCID 15380937 | 83.8% |
반응 단계
A mixture of 4-[[(dimethylamino)methylene]amino]-3-pyridinol (5.00 g), N-methylcyclohexylamine (5.20 g), and anhydrous toluene (50 mL) was heated at reflux under nitrogen for 17 hours. The solution was concentrated under reduced pressure and the crude product chromatographed on silica gel (10% methanol in dichloromethane) to afford 5.92 g of solid. Recrystallization from ethyl acetate/hexanes afforded 4.90 g of crystalline material, m.p. 127°-129° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05869480 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-37c99f83914c4ca58690a7333dfd8aca |
| 출처 메모 | uspto-grants-1999_02 |