Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-[4'-(Azidomethyl)[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)-1H-tetrazole → 2-[4-(Benzyloxy)phenyl]-5-n-butyl-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]-methyl]-3H-1,2,4-triazol-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-[4'-(Azidomethyl)[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)-1H-tetrazole | HCID 14987335 | — |
| 반응물 | 2-[4-(Benzyloxy)phenyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 135720083 | — |
| 생성물 | 2-[4-(Benzyloxy)phenyl]-5-n-butyl-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]-methyl]-3H-1,2,4-triazol-3-one | HCID 19939373 | 81% |
반응 단계
The alkylation of 2-[4-(benzyloxy)phenyl]-5-n-butyl-2.4-dihydro-3H-1,2,4-triazol-3-one with 5-[4'-(bromomethyl)biphenyl-2-yl]-N-trityltetrazole (see Example 2, Step B) was carried out as described in Example 4, Step D. After work-up, flash chromatography over silica gel using 0.4-0.5% MeOH/CH2Cl2 gave an 81% yield of the product, homogeneous by TLC in 1% MeOH/CH2Cl2 ; mass spectrum (FAB) m/e 800 (M+1)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411980 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-093a465b6f5249e6aded118cd695840c |
| 출처 메모 | uspto-grants-1995_05 |